Details: After Peyton's mother died Brooke came by her house everyday to make sure she was okay. Peyton and Brooke where on the cheerleading squad together. Brooke ended the friendship twice but both times they came out stronger. Brooke and Peyton lived together for the last period of high school and after they both came back to Tree Hill. Peyton named her daughter after Brooke, Sawyer Brooke Scott.Brooke was Peyton maid of honor and she made her wedding dress. Peyton could not attend Brooke's wedding due to Sawyer being sick
Details: Haley and Brooke have been best friends since their junior year in high school. one night after a Ravens game Haley drove home with Peyton and Brooke. since then Peyton and Haley started to become closer and Brooke soon became closer with Haley as well. Brooke helped Haley hide her pregnancy from the students at school and Haley and Nathan made Brooke Jamie's godmother. Four years after graduation Brooke moves back to Tree Hill and spends a lot of time with Jamie and Haley to get their minds off Nathan. Haley and Brooke became even closer after Peyton and Lucas left Tree Hill because Lucas was Haley's best friend and Peyton was Brooke's.
Details: Mouth and Brooke's friendship started at the Boytoy auction where Brooke bought Mouth after she had broken up with Lucas and she wanted to have a fun night. Brooke and Mouth have always supported each other. When mouth was going to move to Omaha, Brooke fired Millicent to get her to go with him and she also helped him after Millie had cheated on him with Owen.
Details: Brooke didn't like Rachel at first because she was constantly flirting with Lucas but they packed things up and Brooke even lived with Rachel after she moved out of Peyton's house. When Brooke went to New York with Owen she found Rachel on the floor, she overdosed and Brooke took her back to Tree Hill but Rachel stole some money from Brooke and left.