Details: Karen had a very close relationship with her son, raising him as a teenager and a single parent and helping to instill his morals and help to develop him into the person who he is and he too supported her. And the two have a very close and loving relationship.
Details: Karen fell pregnant very shortly following the death of Lily's father Keith and Karen fell into a deep depression but her pregnancy helped her through it. When Lily was born Karen fell into a coma and dreamed of spending time with Keith and Lily and there he urged her to go back to her daughter. Karen and Lily had a very strong and deep relationship possibly due to Karen being a single parent and raising Lily with the same morals she gave to Lucas (Lily's older brother) and home school Lily and spent all her childhood travelling around the world with her.
Details: Karen is Lucas' single mom and was the first person to hold Sawyer after she was passed over by the nurses. Surprising the others with her presence, Karen has always been there in joyous times and times of need. It is certain that throughout Sawyer's life, Karen will always be there for Sawyer and her family whenever they need her.
Details: Peyton is the daughter-in-law of Karen Roe through her marriage to Lucas Scott. Peyton and Karen have always had a nice relationship. Karen has been well aware of Peyton through Lucas's many trysts with Peyton and Brooke Davis. Karen also used to date Peyton's adoptive father Larry Sawyer. It didn't work out, but Peyton visited Karen afterward and asked if they could still keep in touch because she enjoyed getting to know her. Karen has always known that Peyton was the one for Lucas, along with most of the other characters on the show. Karen also becomes a mother figure for Peyton to go to for advice; as Peyton is not able to go to Anna or Ellie.
Details: It unknown what the relationship between Karen and her father was but it is known that when Karen fell pregnant fell pregnant during high school she had no support from her family nor in the upbringing of her son, Lucas.
Details: It unknown what the relationship between Karen and her mother was but it is known that when Karen fell pregnant fell pregnant during high school she had no support from her family nor in the upbringing of her son, Lucas.