Details: He was her friend for fifteen years. She kissed him before traveling to Florence, Italy. She then found out that Keith had been drinking when driving Lucas to pick Karen up from the airport. When she had finally forgiven him, he asked her to marry him. She said no. After the attempted murder of Dan, Karen finally realized that she loved Keith and they kissed. Keith was then arrested for his attempted murder. Later, Karen asked Keith to marry her with his response telling her that he was going to ask her. Soon after, Dan murdered Keith out of what he thought was getting revenge. Little known then, Keith died leaving Karen pregnant with her second child, a daughter, named Lily.
Details: She is the Lucas's best friend for Karen is like a daughter, because she is always with her and Lucas, works at the cafe and she and Karen will often exchange tips, their friendship is very strong.
Details: They have in common a man, Dan Scott and for the harm he did to Karen and Lucas, Deb comes to the woman becoming her friend, and then also her business partner, the two will have ups and downs, but we will always be the 'one for the' other .
Details: They became friends when Lucas was in the hospital, Karen has helped Peyton at Tric and open and has also helped to manage it, then leaving it in her hands, Karen has also always given advice, and was later also her mother-in-law.
Details: For Brooke also to be a friend, Karen is the former guardian, when Brooke's parents move Karen home to his house and the girl is created between them a kind of bond between mother and daughter.